作为Ritalin的辅助疗法,益生菌在ADHD儿童和青少年中的作用:一项三盲随机对照试验
Zahra Sadat Sangsefidi1, Zohreh Sadat Sangsefidi2, Fatemeh Moharreri1
1Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Nutritional neuroscience
|August 20, 2024
概括
益生菌补充剂在与Ritalin一起使用时,可能会为患有注意力缺陷多动症 (ADHD) 的儿童提供好处. 这种辅助疗法改善了听觉响应控制和一些ADHD症状得分.
科学领域:
- 儿科精神病学 儿科精神病学
- 微生物组研究 微生物组研究
- 药理学 药理学是指药理学的学科.
背景情况:
- 注意缺陷多动性障碍 (ADHD) 是一种普遍存在的儿童心理健康状况.
- 目前关于治疗ADHD的益生菌补充剂的研究是有限的,并产生了相互矛盾的结果.
- 与标准ADHD药物一起研究益生菌等辅助疗法至关重要.
研究的目的:
- 评估益生菌作为Ritalin的补充治疗在被诊断为ADHD的儿童和青少年中的疗效.
- 为了确定特定的益生菌菌株是否可以调节ADHD症状.
主要方法:
- 这是一项随机对照试验,涉及60名伊朗儿科ADHD患者 (4-16岁).
- 参与者接受了一个益生菌组合 (Lactobacillus plantarum PTCC 1896和Bifidobacterium animalis亚种. 乳糖BB-12) 或安慰剂为8周.
- 在基线和随访时,使用康纳斯家长评分表 (CPRS) 和综合视觉和听觉持续表现测试 (IVA/CPT) 评估了ADHD症状.
主要成果:
- 在益生菌组 (p=0.01) 中,在4周后观察到CPRS总得分的显著降低.
- 在8周后,CPRS总分数没有发现显著差异.
- 益生菌组在研究结束时与安慰剂相比,听觉响应控制得分显著增加 (p=0.02).
结论:
- 益生菌补充剂,当与Ritalin相结合时,可能为ADHD患者提供一些好处,包括改善听觉反应控制.
- 需要进行进一步的临床试验,才能确定益生菌在治疗ADHD中的作用.
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