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Updated: Apr 30, 2026

Pooled CRISPR-Based Genetic Screens in Mammalian Cells
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Pooled CRISPR-Based Genetic Screens in Mammalian Cells

Published on: September 4, 2019

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一个统计模拟模型,用于指导阵列CRISPR屏幕实验中分析方法的选择

Chang Sik Kim1, Jonathan Cairns1, Valentina Quarantotti2

  • 1Data Sciences & Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, England.

PloS one
|August 20, 2024
PubMed
概括

我们开发了一个统计模拟模型,以帮助研究人员选择最佳的计算工作流程来分析数组的CRISPR查数据. 该工具有助于选择功能性基因组学实验的适当规范化和呼叫方法.

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Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
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