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Updated: Jun 16, 2025

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在结构上,Gcn2模仿了HisRS酶,并在功能上重新定位了HisRS酶,用于整合应激反应

Charles Bou-Nader1, Swati Gaikwad2, Soheila Bahmanjah1

  • 1Laboratory of Molecular Biology, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.

Proceedings of the National Academy of Sciences of the United States of America
|August 20, 2024
PubMed
概括

蛋白激酶Gcn2的激活依赖于其基-tRNA合成酶 (HisRS) 域. 结构模拟揭示了脱糖的tRNA如何结合这个域,将酶重新用于新的调节功能.

关键词:
GCN4 的翻译.Gcn2 的意思eIF2α的酸化方式这是一种histidyl-tRNA合成酶.酵母 S. cerevisiae 的酵母

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