聚焦超声波:非侵入性图像导向疗法
Chrit T W Moonen1, Joseph P Kilroy, Alexander L Klibanov
1From the Focused Ultrasound Foundation, Charlottesville, VA (C.T.W.M., J.P.K.); and Cardiovascular Division (Department of Medicine) and Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA (A.L.K.).
Investigative radiology
|August 20, 2024
概括
聚焦超声疗法提供了一种非侵入性治疗疾病的方法,利用先进的成像技术进行精确的准和监测. 这种方法提高了安全性和恢复,避免了手术,并使向药物输送,甚至通过血脑屏障.
科学领域:
- 干预性放射学 干预性放射学
- 医疗成像医学成像
- 声学医学是一种声学医学.
背景情况:
- 传统的瘤切除手术是侵入性的,具有风险和延长的恢复时间.
- 最少侵入性技术,如腹腔镜和导管程序已经改善了患者的结果.
- 完全非侵入性方法在降低风险,程序持续时间和恢复期方面提供了进一步的优势.
研究的目的:
- 审查成像能力和图像引导聚焦超声干预方法的方法.
- 突出成像在规划,实时监测和对聚焦超声波治疗的疗效评估中的整合.
- 讨论声敏纳米颗粒在增强聚焦超声疗法的作用.
主要方法:
- 重点是磁共振成像 (MRI) 和超声波用于指导和监测.
- 整合成像用于治疗规划,定义目标区域和识别有风险的器官.
- 实时监控使用温度计,洞穴反和运动控制,以确保安全和准确性.
- 通过除评估和生理参数监测 (例如血液供应) 来评估治疗疗效.
主要成果:
- 聚焦超声波可实现非侵入性局部高热,机械切除和向药物输送.
- 先进的成像,特别是MRI和超声波,对于规划,指导和监测集中式超声波程序至关重要.
- 超声敏微粒子和纳米粒子增强超声波能量沉积,使微血管干预和向药物/基因输送成为可能.
- 血液-大脑屏障的非侵入性开放,以便在大脑中向药物输送,是显著的进步.
结论:
- 图像引导聚焦超声波是一种快速发展的,非侵入性的疾病治疗工具.
- 它比传统的和最少侵入性的外科手术方法提供了显著的优势.
- 进一步的开发有望在干预放射学中得到更广泛的临床应用.
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