从受压力的细胞中释放的氨酸二酸会触发线粒体的转移,以实现组织平衡
Hao Li1,2, Hongping Yu3, Delin Liu1,2
1Department of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
PLoS biology
|August 20, 2024
概括
受到压力的骨细胞释放腺二酸盐 (ADP) 来触发健康细胞的线粒体转移,恢复能量代谢和骨稳定. 这一过程涉及P2Y2和P2Y6受体.
科学领域:
- 细胞生物学 细胞生物学
- 骨生理学 骨生理学
- 线粒体动力学的动力学
背景情况:
- 细胞间的线粒体转移对生理功能至关重要.
- 骨细胞在树突网络中的线粒体转移调节了骨平衡.
- 触发骨细胞线粒体转移的精确机制在很大程度上仍未被探索.
研究的目的:
- 阐明压力骨细胞启动线粒体转移的机制.
- 为了确定参与ADP介导的线粒体转移的信号通路.
- 调查衰老在骨细胞线粒体代谢和转移中的作用.
主要方法:
- 利用小鼠模型研究骨细胞对压力的反应.
- 测量氧气消耗率 (OCR) 和反应性氧物种 (ROS) 水平.
- 研究了细胞外核酸和纯能受体 (P2Y2,P2Y6) 在线粒体转移中的作用.
- 分析了老骨细胞的条件介质及其对线粒体代谢的影响.
主要成果:
- 受到压力的骨细胞释放腺二酸盐 (ADP),触发了健康骨细胞的线粒体转移.
- 线粒体转移恢复了氧气消耗率 (OCR) 并减少了应激细胞中反应性氧物种 (ROS) 的积累.
- 确定P2Y2和P2Y6受体是ADP诱导的线粒体转移的关键信号传感器.
- 衰老的骨细胞表现出线粒体代谢受损和细胞外核酸释放增加,其条件介质增强了骨细胞线粒体转移和能量代谢.
结论:
- 细胞外ADP作为一个关键的信号,以启动骨细胞中细胞间的线粒体转移.
- 通过P2Y2和P2Y6受体进行纯能信号传递,通过健康的骨细胞调解压力骨细胞的救援.
- 衰老会损害骨细胞线粒体功能,改变细胞外核酸信号传递,但会促进补偿性线粒体转移以增强能量代谢.
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