精确定义的合成共聚物与悬浮合物形成生物相容的应变强化水凝,并使竞争性连接体移位成为可能
Ivo A O Beeren1,2, Francis L C Morgan1,2, Timo Rademakers2
1Department of Instructive Biomaterials Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, 6229 ER Maastricht, The Netherlands.
Journal of the American Chemical Society
|August 20, 2024
概括
研究人员使用一种新型合成聚合物开发了新的动态水凝. 这些可适应的生物材料模仿细胞外基质,为组织工程和再生医学应用提供可调节的特性.
科学领域:
- 生物材料科学
- 聚合物化学
- 组织工程
背景情况:
- 动态水凝模仿细胞外基质 (ECM) 特性,如应力强化和应力放松.
- 在动态水凝中越来越多地使用伊胺类型的动态共价化学 (DCvC).
- 合成,侧链修饰的聚合物中存在一个空白.
研究的目的:
- 合成一种新型的水溶性共聚物与可调的悬挂基.
- 将这些共聚物形成动态水凝生物材料.
- 研究水凝的机械特性,细胞兼容性和功能调节的潜力.
主要方法:
- 控制的激素聚合,以合成具有不同含量的共聚物 (12-64%).
- 形成水凝的胺类交联.
- 机械测试以评估硬度和应变硬度.
- 使用人类皮肤纤维细胞的细胞相容性测定.
- 通过竞争性结合来证明连接体的移位.
主要成果:
- 精心控制的聚合物合成与一个块状梯度微架构.
- 通过 imine 交叉连接快速形成水凝.
- 可调节的水凝硬度 (≈220 kPa) 和应变硬化开始 (σc ≈10 Pa).
- 与人类皮肤纤维细胞的细胞相容性已被证明.
- 通过竞争性结合成功调节连接体功能.
结论:
- 实现了多功能,侧链修饰的含有合物的简单合成.
- 这些共聚物形成可调节的,细胞相容的动态水凝,模仿ECM的机械特性.
- 该系统提供了空间时间控制功能,使其适用于先进的生物材料设计.
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