无载体纳米药物:从长椅到床边
Fang Fang1,2, Xiaoyuan Chen1,3,2,4,5
1Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore 119074, Singapore.
ACS nano
|August 20, 2024
概括
无载体纳米药物提供高药物负载和降低毒性疾病治疗. 克服组装,交付和体内命运方面的挑战对于临床翻译至关重要.
科学领域:
- 纳米医学是一种纳米医学.
- 超级神奇主义者 超级神奇
- 药物运输 药物运输 药物运输
背景情况:
- 无载体纳米药物由于高活性药物成分 (API) 载荷,最小载体毒性和简单合成而具有前景.
- 无载体纳米晶体的商业成功凸显了临床潜力.
- 实际翻译面临障碍:无法预测的组装,低交付效率和不清楚的体内行为.
研究的目的:
- 系统地审查当代和新兴的无载体纳米药物.
- 突出这些纳米药物的临床转化机会和挑战.
主要方法:
- 基于现有文献和新兴趋势的视角审查.
- 分析各种API及其在无载体纳米药物中的配方.
- 讨论临床翻译障碍和未来方向.
主要成果:
- 无载体纳米药物能够实现特殊的API负载 (高达100%),并避免载体诱导的毒性.
- 尽管有潜力,可预测的组装,高效的交付和了解体内命运的挑战仍然存在.
- 目前正在探索各种API,以开发无载体纳米医学.
结论:
- 无载体纳米药物为疾病治疗学提供了重大机会.
- 设计,准备,交付,疗效和安全方面的改进对于成功的临床转化至关重要.
- 需要进一步的研究,以弥合这些先进治疗方法的差距.
更多相关视频
07:59A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
Published on: March 4, 2017
8.9K
08:47Experimental Quantification of Interactions Between Drug Delivery Systems and Cells In Vitro: A Guide for Preclinical Nanomedicine Evaluation
Published on: September 28, 2022
1.9K
相关概念视频
01:24Cellular Membranes and Drug Transport
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
01:24Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.