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蜂通过向MKK4通路来抑制亚托皮炎
Ye-Ryeong Cho1, Eui Jeong Han2, Eun Heo1
1Department of Biotechnology, Yonsei University, Seoul, Republic of Korea.
BioFactors (Oxford, England)
|August 20, 2024
概括
蜂的消费可以通过减少炎症和恢复皮肤屏障功能来有效治疗阿托皮炎 (AD). 它的活性化合物咖啡酸乙烯 (CAPE) 向MKK4,为AD提供一种天然的治疗方法.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 自然产品 化学 化学
背景情况:
- 蜂是一种来自蜜蜂的树脂,以其生物活性而闻名.
- 它对亚托皮性皮炎 (AD) 的治疗潜力在很大程度上尚未被探索.
- 阿尔茨海默病是一种慢性炎症性皮肤疾病,皮肤屏障功能受损.
研究的目的:
- 调查在治疗阿托皮性皮炎 (AD) 中的疗效.
- 为了确定中的活性化合物,负责治疗效果.
- 阐明在AD中的作用背后的分子机制.
主要方法:
- 在体外研究中使用HaCaT角质细胞来评估细胞因子和化学因子分泌以及屏障蛋白表达.
- 在类似AD的人类皮肤样本上的ex vivo分析.
- 在体内研究使用DNCB诱导的AD小鼠模型来评估临床症状,屏障功能和基因表达.
- 化学分析以确定活性化合物,其次是针对MKK4的机械学研究.
主要成果:
- 可以抑制关键的炎症媒介 (IL-6,IL-8,MCP-1,MDC) 和恢复皮肤屏障蛋白 (filaggrin,involutrin) 在体外和体外皮肤模型中.
- 在小鼠中,口服 прополис减轻了AD症状,改善了皮肤屏障,减少了伤,并使AD相关基因表达正常化.
- 咖啡酸乙烯 (CAPE) 被确定为活性化合物.
- 和CAPE都直接针对MKK4.
结论:
- 蜂显示出对亚托邦性皮炎 (AD) 的显著治疗潜力.
- 该机制涉及抑制炎症途径和恢复皮肤屏障功能,由CAPE调解,准MKK4.
- 可以被认为是AD管理的功能性食品剂.
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