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Updated: Jun 16, 2025

A Free-breathing fMRI Method to Study Human Olfactory Function

A Free-breathing fMRI Method to Study Human Olfactory Function

Published on: July 30, 2017

在气味刺激期间主观认知衰退中,初级嗅觉皮质-海马体-额叶皮质的功能连接性发生变化

Xin Zhang¹, Yajing Zhu², Jiaming Lu³

¹Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China.

Human brain mapping

|August 20, 2024

概括

主观认知衰退 (SCD) 显示了嗅觉回路中大脑连接的改变,即使结构和行为稳定. 这些功能连接性变化可能成为阿尔茨海默病风险的早期标志物.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
认知科学认知科学

背景情况:

主观认知衰退 (SCD) 代表了临床前阿尔茨海默病 (AD) 的高风险组.
嗅觉功能障碍被认为是痴呆症进展的危险因素.
了解SCD早期的神经变化对于及时干预至关重要.

研究的目的:

调查SCD受试者在嗅觉刺激期间嗅觉神经回路的功能连接 (FC) 变化.
为了比较SCD个体和正常对照 (NCs) 之间的FC模式.
探索神经成像发现,嗅觉行为和认知功能之间的相关性.

主要方法:

在嗅觉刺激期间的功能磁共振成像 (fMRI).
用于FC评估的通用心理生理相互作用分析.
脑区域激活,体积差异和行为/认知分数的比较.

主要成果:

SCD受试者表现出双边初级嗅觉皮层 (bPOC) 与右海马之间减少的FC,以及右海马与右前皮层之间增加的FC.
在SCD和NC组之间没有发现bPOC激活,嗅觉行为或大脑区域体积的显著差异.
观察到大脑区域体积/激活和嗅觉/认知性能之间的相关性.

结论:

在SCD中,嗅觉-皮质电路内的功能连接受到改变,尽管嗅觉行为和大脑结构稳定.
在POC-海马体-额叶皮层通路中的改变的FC可以作为早期AD检测的敏感成像生物标志物.
这些发现强调了基于fMRI的FC分析在识别患AD高风险个体方面的潜力.

关键词:

在 POC POC POC 中.额叶皮层的前部皮层.gPPI 的意思是在海马体内,海马体嗅觉fMRI的使用方法主观认知衰退主观认知衰退

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