甲福明通过激活NRF2/HO-1/NF-κB通路,减轻新生小鼠白质损伤
Weiwei Xie1, Bingqing Ding2, Jia Lou2
1Department of Pediatrics, the Second School of Medicine, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Department of Pediatrics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, 150 Ximen Street, Linhai, Zhejiang, China.
International immunopharmacology
|August 20, 2024
概括
甲胺 (MET) 在保护新生小鼠免受白质损伤 (WMI) 方面表现有前途. 这项研究发现,MET通过激活NRF2/HO-1/NF-κB通路,改善了髓完整性和认知功能.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 早产婴儿的白质损伤 (WMI) 会导致严重的终身残疾.
- 甲胺 (MET) 已知具有潜在的神经保护作用,但其在WMI中的作用尚未完全理解.
研究的目的:
- 在新生儿小鼠模型中研究甲福明对新生儿白质损伤的神经保护作用.
- 阐明甲胺在WMI中的作用的潜在分子机制.
主要方法:
- 在新生小鼠中建立了慢性缺氧诱导的WMI模型.
- 施用了甲胺并评估了髓基本蛋白 (MBP),Olig2,CC1表达,髓盖完整性,氧化应激和微质透.
- 评估行为结果,包括记忆,学习,运动能力和类似焦虑的行为.
- 研究了NRF2/HO-1/NF-κB通路的作用,并使用了NRF2抑制剂ML385.
主要成果:
- 甲胺治疗增加了MBP,Olig2和CC1的表达,增强了髓盖的厚度和密度.
- 在WMI模型中,MET减少了氧化应激和微质透.
- 用MET治疗的小鼠表现出更好的记忆力,学习能力,运动功能,以及减少类似焦虑的行为.
- 这些效应与NRF2/HO-1/NF-κB通路的上调相关,ML385.5的逆转证明了这一点.
结论:
- 在新生小鼠中,甲福明有效减轻慢性缺氧诱导的白质损伤.
- 甲福明的神经保护作用通过激活NRF2/HO-1/NF-κB通路进行介导.
- 甲胺代表了治疗白质损伤的潜在治疗策略.
相关概念视频
02:26NF-κB-dependent Signaling Pathway
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
02:26NF-kB-dependent Signaling Pathway
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...