在创伤患者和阿片类药物使用障碍中的布普伦诺芬诱导 - 一个单一中心的经验?
Erica Roth1, Amanda Bingaman2, Sam Stern3
1Department of Surgery, Temple University Hospital, Philadelphia, Pennsylvania.
The Journal of surgical research
|August 20, 2024
概括
布普伦诺芬微诱导在创伤患者中显示出高完成率,类似于传统的诱导. 完成布普伦诺芬治疗增加了家庭出院的可能性和阿片类药物使用障碍的门诊随访.
科学领域:
- 创伤外科 手术 创伤外科
- 成 药物 药物 药物 药物
- 药理学 药理学是指药理学的学科.
背景情况:
- 布普伦诺芬是一种有效的FDA批准的治疗阿片类药物使用障碍 (OUD).
- 低剂量布普伦诺芬启动 (微诱导) 为患者过渡提供了一种新的方法.
- 创伤患者经常经历OUD,并且可能有患者指导性出院 (PDD).
研究的目的:
- 为了比较布普伦诺芬微诱导与创伤患者的传统诱导.
- 评估启动方法对协议完成和PDD的影响.
- 评估与创伤护理中成功诱导布普伦诺芬相关的因素.
主要方法:
- 城市一级创伤中心的回顾性队列研究 (2020年12月 - 2022年6月).
- 包括18-89岁的受伤患者接受布普伦诺芬治疗.
- 主要结局:完成住院方案 (16 mg布普伦诺芬在24小时内或稳定剂量).
主要成果:
- 微诱导 (46名患者) 和传统诱导 (52名患者) (P=0.29) 之间没有显著的协议完成差异.
- 总体而言,协议完成率为83%.
- 完成协议的人更有可能被送回家 (P=0.0002),PDD更少 (P=0.001),门诊成诊所随访增加 (P=0.038).
结论:
- 在创伤患者中,不管协议类型如何,布普伦诺芬诱导是可行的,其完成率很高.
- 成功完成布普伦诺芬诱导与改善出院处置和出院后护理参与有关.
- 这些发现支持在创伤环境中实施布普伦诺芬诱导协议,以管理阿片类药物使用障碍.
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