个人化语言下免疫疗法与动态维护剂量上升,用于室内灰尘虫引起的过敏性鼻炎
Juan Wang1, Ling Cai1, Caiqin Huang1
1Department of Otolaryngology, The Affiliated Jiang Ning Hospital of Nanjing Medical University, Nanjing 211100, China.
American journal of otolaryngology
|August 20, 2024
概括
针对家用粉尘虫 (HDM) 的动态高剂量疗法和舌下免疫疗法 (SLIT) 改善了过敏性鼻炎 (AR) 症状,比标准剂量更有效. 这种对HDM-SLIT的个性化方法对AR患者来说是安全的和可行的.
科学领域:
- 过敏原免疫疗法免疫疗法
- 免疫学 免疫学 免疫学
- 呼吸系统药物 呼吸系统药物
背景情况:
- 针对家用灰尘虫 (HDM) 的舌下免疫疗法 (SLIT) 的精确剂量正在研究中.
- 缺少HDM-SLIT的标准化剂量调整模式.
- 本研究探讨了针对个性化SLIT的动态维护剂量上升方案的临床可行性.
研究的目的:
- 对个性化HDM-SLIT进行动态维护剂量上升方案的临床可行性进行研究.
- 在过敏性鼻炎 (AR) 患者中,比较高剂量 (HD) 治疗方案与常用剂量 (RD) 治疗方案的疗效和安全性.
主要方法:
- 对258名AR患者进行了回顾性研究,这些患者接受了HDM-SLIT治疗.
- 患者分为 RD 组 (n=101) 和 HD 组 (n=157).
- 通过综合症状和药物评分 (CSMS) 和视觉模拟尺度 (VAS) 评估有效性;通过不良事件 (AE) 评估安全性.
主要成果:
- 无论是RD和HD组,CSMS和VAS在2年内从基线显著减少 (P <0.05).
- 与RD组相比,HD组在临床参数方面表现出更大的改善 (P < 0.05).
- 在年龄分组之间或在RD和HD组之间没有观察到有效性或AE发生率的显著差异.
结论:
- 具有动态维护剂量上升方案的2年HDM-SLIT是AR患者的有效和安全治疗方法.
- 这种个性化剂量调整模式在临床实践中为AR患者提供了潜在的好处.
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