在GnRH刺激试验中测量的平均峰值LH水平的诊断实用性
Serkan Bilge Koca1, Hüseyin Demirbilek2
1Kayseri City Education and Research Hospital, Department of Pediatrics, Division of Pediatric Endocrinology, Kayseri, Türkiye.
Journal of pediatric endocrinology & metabolism : JPEM
|August 20, 2024
概括
在性激素释放激素 (GnRH) 测试期间从两次测量中性激素 (LH) 水平的平均值可靠地诊断出中心早期青春期 (CPP). 这种方法有助于临界LH水平的病例,改善下丘脑-垂体-淋巴腺轴的诊断准确度.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生殖医学 生殖医学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 淋巴激素释放激素 (GnRH) 测试对于通过评估下丘脑-垂体-淋巴腺 (HPG) 轴来诊断中心早熟性青春期 (CPP) 是至关重要的.
- 在标准的GnRH刺激测试期间,在边界峰值白化激素 (LH) 水平的情况下,诊断CPP可能具有挑战性.
研究的目的:
- 为了评估使用在GnRH刺激测试期间多次测量的LH水平平均值的诊断性能.
- 建立一种可靠的方法来区分中央早发性青春期 (CPP) 和早发性青春期 (PT),特别是在模两可的情况下.
主要方法:
- 追溯审查GnRH刺激测试结果在女孩被诊断为CPP和过早的thelarche (PT).
- 通过电化学发光免疫测试 (ECLIA) 测量的人类测量数据,生长速度,青春期阶段,骨龄和血清激素水平 (FSH,LH,雌激素) 的分析.
- 在GnRH刺激测试期间,LH和FSH水平在基底,第20分钟和第40分钟被测量.
主要成果:
- 总共有76名女孩 (38名CPP,38名PT) 进行了分析.
- 平均峰值LH切断值为4.25 IU/L,表明诊断的准确性很高.
- 拟议的方法在区分CPP和PT时,获得了94.7%的灵敏度,97.4%的特异性,97.3%的积极预测值和94.9%的负预测值.
结论:
- 在GnRH刺激试验中,两次LH测量的平均值是评估HPG轴激活的有效和可靠工具.
- 这种方法提供了更好的诊断实用性,特别是在临界峰值LH水平的患者中.
- 这项研究首次证明了在GnRH测试中平均LH水平的诊断价值,用于CPP评估.
相关概念视频
Hormonal Regulation of the Menstrual Cycle
320
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
320
Testosterone: Functions and Regulation
588
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
588


