产生GABA的乳酸菌可以增加对负面情绪的认知反应,但不会改善认知表现:人类双盲安慰剂控制的交叉研究
Melania Casertano1, Matthijs Dekker2, Vincenzo Valentino3
1Food Quality & Design Group, Wageningen University & Research, NL-6708 WG, the Netherlands; Department of Agricultural Sciences of the University of Naples "Federico II", Università 100, 80055 Portici (NA), Italy.
Brain, behavior, and immunity
|August 20, 2024
概括
这项研究发现,一种含有Levilactobacillus brevis P30021和Lactiplantibacillus plantarum P30025的特定益生菌配方改善了抑郁症状,并减少了中度压力成人反. 这种精神生物制剂显示出增强心理健康的潜力.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
背景情况:
- 精神病菌细菌,包括Levilactobacillus brevis P30021和Lactiplantibacillus plantarum P30025,是已知的影响压力,睡眠和认知的益生菌.
- 之前的体外研究已经确定了这些菌株是GABA和乙胆的生产者,这表明它具有潜在的心理作用.
研究的目的:
- 评估益生菌配方在缓解中度压力健康成年人的认知表现方面的疗效.
- 评估二次结果,包括情绪,神经递质生产 (GABA,谷氨酸,乙胆,胆) 和肠道微生物群组成.
主要方法:
- 一项为期12周的随机,双盲,安慰剂控制,交叉研究,涉及44名健康成年人,他们有轻度至中度的压力 (DASS-42分数).
- 用CogState电池测试来评估认知功能.
- 参与者接受了益生菌配方或安慰剂.
主要成果:
- 益生菌配方显著降低了对悲伤情绪的认知反应能力 (p=0.034) 并改善了反 (p=0.006).
- 没有观察到对主观压力指标的显著影响.
- 呈阳性反应者在肠道微生物群中显示出益生菌属 (乳杆菌和L. brevis) 的丰富性增加.
结论:
- 研究的益生菌制剂显示出作为减轻负面情绪感觉的精神病菌的潜力.
- 需要对更大的样本大小和更长的干预期进行进一步的研究,以确认对压力相关疾病的影响.
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