优化连续旋冷干燥过程的二次干燥阶段:一种半机械模型方法
Laurens Leys1, Thomas De Beer1
1Laboratory of Pharmaceutical Process Analytical Technology, Department of Pharmaceutical Analysis, Ghent University, Ghent, 9000, Belgium.
International journal of pharmaceutics
|August 20, 2024
概括
连续旋转冷干燥在批量方法上具有优势. 这项研究开发了一种用于二次干燥阶段的新模型,提高了预测准确度,并实现了更好的过程控制.
科学领域:
- 制药工程 制药工程
- 化学工程是化学工程的重要组成部分.
- 食品科学 食品科学 食品科学
背景情况:
- 连续旋转冷干燥是一种先进的替代传统批量冷干燥.
- 优先考虑的是初级干燥阶段的优化,但二次干燥也至关重要.
- 现有的批量冷干燥的脱吸模型不能完全捕捉连续旋转冷干燥的动态.
研究的目的:
- 开发一个半机械模型,用于连续旋转冷干燥中的二次干燥阶段.
- 研究结速率和产品温度对脱吸动力学的影响.
- 通过解决与常规模型的差异来提高脱吸模型的准确性.
主要方法:
- 开发一种半机械模型,其中包含依赖于水分的剩余激活能量.
- 使用近红外 (NIR) 光谱仪进行参数估计.
- 雇员红外 (IR) 温度计用于实时温度监测.
主要成果:
- 该模型准确地预测了测量值的0.11%内的最终水分含量.
- 通过快速程序成功估计了未知的模型参数.
- 在新条件下证明可靠地预测产品温度和残留湿度.
结论:
- 开发的半机械模型增强了在连续旋转冷干燥中对二次干燥阶段的理解.
- 该模型为预测过程结果和优化条件提供了可靠的工具.
- 允许创建一个实用的设计空间,以提高工艺效率和产品质量.
相关概念视频
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
442
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
442
Drying Shrinkage
530
When hardened concrete is exposed to air with a relative humidity of less than 100 percent, it begins to lose the free water within its capillaries. As this water evaporates, the water initially adsorbed onto the calcium silicate hydrates migrates towards these now empty spaces and eventually evaporates as well. Over time, as more water leaves, the volume of the concrete decreases, a phenomenon known as drying shrinkage.
A portion of this drying shrinkage can be reversed; if the concrete is...
A portion of this drying shrinkage can be reversed; if the concrete is...
530


