多种血液金属与心脏结构和功能的关联:在CAD人群中的横截面研究
Yapei Sun1, Qi Mao2, Denglu Zhou2
1Center of Laboratory Medicine, Chongqing Prevention and Treatment Center for Occupational Diseases, Chongqing, 400060, China; Chongqing Key Laboratory of Prevention and Treatment for Occupational Diseases and Poisoning, Chongqing, 400060, China.
混合金属暴露对冠状动脉疾病 (CAD) 患者的心脏结构和功能产生负面影响. 铜和是主要的贡献者,而或锡可能提供保护性益处.
科学领域:
- 环境健康 环境健康
- 心血管医学 心血管医学
- 毒理学 毒理学 毒理学
背景情况:
- 冠状动脉疾病 (CAD) 与心脏结构和功能异常有关,增加预后风险.
- 混合金属暴露对CAD患者心脏健康的影响仍未得到充分研究.
研究的目的:
- 调查金属混合物与心脏结构/功能在CAD患者之间的关联.
- 探索金属之间的潜在相互作用及其对心血管参数的影响.
主要方法:
- 在中国西南地区对1555名CAD患者进行横截面研究.
- 使用感应合血谱测量14种金属的血度.
- 通过心声学评估心脏结构和功能;使用贝叶斯内核机器回归和线性回归分析数据.
主要成果:
- 混合金属暴露显示出显著的负面关联与心脏结构在第60个百分点以下.
- 增加的金属水平 (第50至第75百分位数) 与左心室射出分数和分数缩短的减少相关.
- 铜和呈现负相关性,而,和与心脏参数呈现正相关性. 在铜-锡和-金属混合物之间观察到敌对的相互作用.
结论:
- 混合金属暴露对冠状动脉疾病患者的心脏结构和功能产生不利影响.
- 铜和是这些负面影响的主要原因.
- 或锡补充剂可以减轻某些金属对心血管的不良影响.
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