营养遗传学和营养策略在全身性动脉高血压:从一个范围审查的证据
Luciana C Holzbach1,2, Paula N Brandão-Lima3, Graziela B S Duarte3
1Nutritional Genomics Research Group, Graduate Program in Nutrition and Health, School of Nutrition, Federal University of Goiás, Goiânia 74605080, Brazil.
Nutrition reviews
|August 20, 2024
概括
基因-营养物相互作用会影响系统性动脉高血压 (SAH) 的血压 (BP). 有限的证据表明,和利博与遗传变异相互作用,但机制需要进一步研究.
科学领域:
- 心血管遗传学 心血管遗传学
- 营养科学 营养科学
- 精准医学是一门精准的医学.
背景情况:
- 系统性动脉高血压 (SAH) 受营养和遗传学的影响.
- 基因-营养物相互作用在调节血压 (BP) 中发挥作用.
研究的目的:
- 审查对影响SAH成年人BP的基因营养相互作用的现有证据.
- 识别特定的基因,单核酸多态 (SNP) 和参与BP调节的营养物质.
主要方法:
- 按照乔安娜·布里格斯研究所和PRISMA-Scoping的指导方针进行系统审查.
- 包括12项研究,检查了20个基因和31个与BP变异相关的SNP.
- 专注于营养干预措施,特别是饮食中的含量.
主要成果:
- 在31个评估的SNP中,有19个与血压变化有关.
- ACE rs4646994和AT1R rs5186是经常研究的SNP.
- 对多个SNP (例如KDM1A rs587168,ACE rs4646994,AT1R rs5186) 观察到与摄入的相互作用.
- 特定的SNP (AT2R rs11091046,MTHFR rs1801133) 分别显示与饮食模式和利博弗拉的相互作用.
结论:
- 目前,关于SAH中血压的基因饮食相互作用的证据有限.
- 观察到的相互作用包括具有特定遗传多态的,和 рибофлавин.
- 这些基因-营养物相互作用的潜在机制在很大程度上仍未确定.
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