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在年轻的儿科癌症幸存者中,并发性肉症和低骨矿物质密度
Andres Marmol-Perez1,2, Esther Ubago-Guisado1,3, Jose J Gil-Cosano1,4
1Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Journal of cachexia, sarcopenia and muscle
|August 20, 2024
概括
年轻的癌症幸存者与sarcopenia有较高的低骨矿物质密度的风险. 建议在这个易受伤害的群体中进行早期的抵抗训练干预,以预防骨质沙症.
科学领域:
- 儿科瘤学 儿科瘤学
- 肌肉骨健康 肌肉骨健康
- 癌症的生存率 癌症的生存率
背景情况:
- 在儿童癌症治疗后,肉症和低骨矿物质密度 (aBMD) 是常见的.
- 在年轻的幸存者中,sarcopenia和aBMD之间的关系尚不清楚.
- 这项研究调查了基于年轻癌症幸存者的肉症状况的aBMD差异.
研究的目的:
- 为了评估骨矿物质密度 (aBMD) 差异在年轻的癌症幸存者根据sarcopenia状态.
- 为了确定低aBMDZ分数的风险,在幸存者可能或确诊的肉症.
主要方法:
- 对116名儿童癌症幸存者 (12.1±3.3年) 的横截面研究.
- 使用双能X射线吸收计评估肌肉强度 (手握),尾瘦肉质量指数 (ALMI) 和aBMD.
- 根据肌肉强度和ALMI Z-score定义了肉;使用调整后回归模型分析了aBMD和低aBMD Z-score的几率比率.
主要成果:
- 与没有肉症的幸存者相比,在多个部位上,被证实患有肉症的幸存者具有显著较低的aBMD (P < 0.001).
- 确定的肉类与全身 (OR:6.91),全部 (OR:2.98) 和大腿部 (OR:4.72) 的低aBMD Z-score风险更高.
- 可能的肉也增加了低全身aBMD的风险 (OR:4.13).
结论:
- 年轻的儿科癌症幸存者患有肉症面临低骨矿物质密度的高风险.
- 及早实施抵抗训练干预措施对于减轻这一群体的骨质疏松症至关重要.
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