大规模大脑状态动态对引起对大脑刺激反应的影响
Amin Kabir1, Prabhjot Dhami1, Marie-Anne Dussault Gomez1
1Centre for Engineering-Led Brain Research, School of Mechatronic Systems Engineering, Simon Fraser University, Surrey, British Columbia V3T 0A3, Canada.
概括
大脑活动动态显著影响神经刺激结果. 在特定的大脑状态 (Microstate C) 期间的跨磁刺激 (TMS) 产生了更大的反应,这表明动态的大脑状态是神经治疗的关键.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
背景情况:
- 了解自发大脑活动在神经刺激中的作用,对于推进神经治疗和脑计算机接口至关重要.
- 虽然已知局部活动的影响,但快速波动的大规模大脑动态的影响仍然未被探索.
研究的目的:
- 为了研究由微状态识别的动态全球大脑状态如何影响神经刺激期间唤起的大脑响应的大小.
主要方法:
- 结合跨磁刺激 (TMS) 和脑电图 (EEG) 来刺激前额叶皮层.
- 对与不同微状态模式相关的唤起大脑反应的分析.
主要成果:
- 在正规的微状态C期间的跨磁刺激 (TMS) 与其他微状态相比,诱导的唤起响应高达80毫秒,显著更大.
- 这种效应可以在不同会议中重现,在假刺激期间缺席,并在独立的数据集中得到验证.
结论:
- 通过微状态捕捉到的快速波动的全球大脑状态,会影响神经刺激结果.
- 这些动态可能反映了大脑连接和兴奋抑制平衡的内在变化.
- 建议考虑动态大脑状态,以优化神经刺激范式.
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