Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Tumor Immunotherapy01:27

Tumor Immunotherapy

493
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
493
The Extracellular Matrix01:29

The Extracellular Matrix

8.9K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
8.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Enhanced stability and sustained delivery of structurally dense DNA nanostructures <i>via</i> a biodegradable hydrogel platform.

Nanoscale horizons·2026
Same author

Engineering T Cells with Membrane-Anchored Nitric Oxide Scavengers for Anticancer Therapy.

ACS nano·2026
Same author

Jammed Foamed Microgel-based Bioprinting for Ex Vivo Reconstruction of 3D T Cell-Cancer Cell Interactions.

Advanced healthcare materials·2025
Same author

Tumor-priming CD8<sup>+</sup> natural killer T-like cells as an efficient novel cell therapy for relapsed/refractory multiple myeloma.

Experimental hematology & oncology·2025
Same author

Cytotoxic Chemotherapy in a 3D Microfluidic Device Induces Dendritic Cell Recruitment and Trogocytosis of Cancer Cells.

Cancer immunology research·2025
Same author

Advancing Allogeneic NK Cell Immunotherapy through Microfluidic Gene Delivery.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same journal

IL-33 scripts cancer immunity.

Trends in immunology·2026
Same journal

Mitochondrial Ca<sup>2+</sup> signaling: A metabolic rheostat defining tumor and immune cell fate.

Trends in immunology·2026
Same journal

Cross-priming underlies the efficacy of antibody-drug conjugates and immunotherapy combinations.

Trends in immunology·2026
Same journal

Gut microbiome metabolites meet immunometabolism in inflammatory bowel disease.

Trends in immunology·2026
Same journal

Metabolic regulatory nodes of the inflammasome and inflammatory cell death.

Trends in immunology·2026
Same journal

Parental leave in immunology - 6.

Trends in immunology·2026
查看所有相关文章

相关实验视频

Updated: Jun 16, 2025

Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy
09:00

Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy

Published on: April 22, 2014

19.1K

固体瘤免疫治疗中的细胞外基质.

Yongbum Cho1, Junsang Doh2

  • 1Research Institute of Advanced Materials (RIAM), Seoul National University, Seoul, South Korea.

Trends in immunology
|August 20, 2024
PubMed
概括
此摘要是机器生成的。

瘤细胞外基质 (ECM) 通过限制运动和改变细胞表型来阻碍CD8+ T和NK细胞的抗瘤功能. 固体瘤免疫治疗的策略必须考虑这些复杂的相互作用.

关键词:
生物工程工具是生物工程工具.细胞毒性淋巴细胞细胞外矩阵是细胞外矩阵.固体瘤是一个固体瘤.瘤ECM是指瘤的ECM.

更多相关视频

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
05:48

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

Published on: March 18, 2014

9.8K
Heteromulticellular Stromal Cells in Scaffold-free 3D Cultures of Epithelial Cancer Cells to Drive Invasion
09:18

Heteromulticellular Stromal Cells in Scaffold-free 3D Cultures of Epithelial Cancer Cells to Drive Invasion

Published on: April 4, 2025

451

相关实验视频

Last Updated: Jun 16, 2025

Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy
09:00

Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy

Published on: April 22, 2014

19.1K
Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
05:48

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

Published on: March 18, 2014

9.8K
Heteromulticellular Stromal Cells in Scaffold-free 3D Cultures of Epithelial Cancer Cells to Drive Invasion
09:18

Heteromulticellular Stromal Cells in Scaffold-free 3D Cultures of Epithelial Cancer Cells to Drive Invasion

Published on: April 4, 2025

451

科学领域:

  • 免疫学 免疫学 免疫学
  • 生物材料科学 生物材料科学
  • 癌症生物学 癌症生物学

背景情况:

  • 瘤细胞外基质 (ECM) 在固体瘤中显著影响细胞毒性淋巴细胞 (包括CD8+ T细胞和自然杀手细胞) 的疗效.
  • 该ECM呈现物理障碍,阻碍免疫细胞运动,并直接修改免疫细胞表型和功能.
  • 它还间接影响免疫突触中细胞毒性淋巴细胞和癌细胞之间的关键相互作用.

研究的目的:

  • 突出瘤细胞外基质 (ECM) 在通过CD8+ T细胞和NK细胞调节抗瘤免疫的关键作用.
  • 强调需要考虑细胞毒性淋巴细胞,癌细胞和瘤ECM之间的复杂相互作用,以开发有效的固体瘤免疫疗法.
  • 要强调仿制瘤ECM特征的生物工程工具的价值,用于基础研究和翻译应用.

主要方法:

  • 对瘤ECM对细胞毒性淋巴细胞功能影响的现有文献的审查和综合.
  • 讨论ECM对T细胞和NK细胞产生的物理和功能变化.
  • 探索新的生物工程方法,如3D ECM模型和微流体学,以研究这些相互作用.

主要成果:

  • 瘤ECM限制了CD8+ T细胞和NK细胞的运动性,在瘤微环境中创建物理障碍.
  • 该ECM直接改变这些细胞毒性淋巴细胞的表型和功能.
  • ECM间接影响免疫细胞和癌细胞之间的免疫突触的形成和有效性.

结论:

  • 有效的固体瘤免疫疗法策略必须整合对复杂的三元相互作用的理解,包括细胞毒性淋巴细胞,癌细胞和瘤ECM.
  • 复制瘤ECM关键特征的生物工程工具对于在癌症免疫治疗中推进基础研究和翻译应用至关重要.
  • 使用先进模型对这些相互作用进行进一步的研究将有助于开发更强效和更有针对性的免疫疗法.