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血液透析患者的下肢功能和心血管疾病风险:一个多中心横截面研究
1Department of Nephrology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Physiological reports
|August 20, 2024
概括
以短物理性能电池 (SPPB) 评分来衡量下肢功能,与血液透析患者的心血管疾病 (CVD) 风险有显著联系. 下肢功能受损预测心血管疾病风险更高,突出其在患者管理中的重要性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 物理医学 物理医学
背景情况:
- 血液透析患者的体力表现下降很常见,影响心血管疾病 (CVD) 发病率和死亡率.
- 在这个人群中,下肢功能对心血管疾病风险的特定作用仍未得到充分研究.
研究的目的:
- 量化下肢功能与血液透析患者心血管疾病风险之间的关联.
- 确定下肢功能是否是该队列中心血管疾病风险的独立预测因素.
主要方法:
- 一项涉及中国上海868名血液透析患者的多中心横截面研究.
- 使用短物理性能电池 (SPPB) 评分 (0-12) 评估下肢功能.
- 用弗雷明汉风险评分评估心血管疾病风险;用握力评估上肢功能.
主要成果:
- 大约35%的患者表现出下肢功能受损 (SPPB<10).
- 较高的SPPB分数与更强的握力和较低的心血管疾病风险相关 (p < 0.05).
- SPPB得分独立预测心血管疾病风险,作为分类 (OR:0.577) 和连续 (OR:0.858) 变量 (p < 0.01). 一个SPPB得分<10预测心血管疾病风险增加 (AUC:0.649).
结论:
- 由SPPB评估的下肢功能与血液透析患者的心血管疾病风险有显著的相关性.
- 下肢功能受损是该人群中心血管疾病风险增加的独立预测因素.
- 需要进一步的研究来探索身体表现和心血管疾病风险之间的长期关系和因果关系.
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