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Updated: Jun 16, 2025

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
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在重症患者中对美罗的生理学基础的药理动力学/药理动力学建模

Yujie Yang1, Yirong Wang1, Wei Zeng2

  • 1Department of Pharmacy, The Third People's Hospital of Chengdu, College of Medicine, Southwest Jiaotong University, Chengdu, China.

Scientific reports
|August 20, 2024
PubMed
概括

这项研究开发了一种基于生理学的药理动力学/药理动力学 (PBPK/PD) 模型,用于重症患者的美罗. 该PBPK/PD模型准确地预测了美罗胺的处置,指导了优化剂量策略,以改善患者的治疗结果.

关键词:
危急病患者的病情非常严重.梅罗佩内姆 (Meropenem) 是一种美的成分.在PBPK/PD中使用.这就是PK-Sim.

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses11:17

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