印度的ASD试验对象缺乏25 ((OH) D和维生素D结合蛋白质,其严重程度更高
Sayanti Shom1, Sharmistha Saha1, Mahasweta Chatterjee1
1Manovikas Biomedical Research and Diagnostic Centre, Manovikas Kendra, 482 Madudah, Plot I-24, Sector J, EM Bypass, Kolkata, West Bengal, 700107, India.
Scientific reports
|August 20, 2024
概括
维生素D结合蛋白 (DBP) 缺乏和特定的遗传变异可能导致自闭症谱系障碍 (ASD) 的严重程度. 在ASD患者中观察到较低的DBP水平和表达,这表明与维生素D缺乏有关.
科学领域:
- 遗传学 是一个遗传学.
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
背景情况:
- 自闭症谱系障碍 (ASD) 的严重程度各不相同,原因不明.
- 维生素D (VitD) 缺乏是ASD的潜在危险因素.
- 维生素D结合蛋白 (DBP) 携带维生素D,其功能可能会受到遗传多态化的影响.
研究的目的:
- 调查DBP遗传多态,DBP水平和ASD之间的关联.
- 探索DBP变异与ASD症状严重程度之间的关系.
- 确定DBP缺乏是否有助于ASD中的25(OH) D缺乏.
主要方法:
- 在印度-高加索亚裔ASD试验者和对照者中分析了DBP遗传多态 (rs7041,rs4588,rs3755967).
- 测量了血中的25...OH) D和DBP水平.
- 在ASD和对照组中评估DBPmRNA表达.
主要成果:
- 特定的DBP基因型 (rs7041 CC,rs4588 TT,rs3755967 TT) 和"A-T"亚型与更高的ASD特征得分有关.
- 与神经类型受试者相比,ASD试验对象的血25~OH) D和DBP水平显著降低.
- 在ASD试验者中,DBP mRNA表达也明显较低.
结论:
- 缺少DBP,尤其是特定的遗传变异,可能是导致ASD维生素D缺乏的一个因素.
- 在DBP的遗传变异可能会影响ASD的严重程度.
- 这些发现突出了DBP在ASD和维生素D代谢的背景下的作用.
关键词:
25 (((OH) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D)在ASD中,使用的是ASD.DBP DBP DBP 的意思是说.rs375596767 这是一个很好的选择.没有Rs458888的费用没有 rs7041更多相关视频
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