通过STAT3/IL-10/PD-L1通路,EBV + B细胞衍生外体促进与EBV相关的T/NK细胞淋巴增殖性疾病免疫逃避

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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

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Wei Chen1, Yao Xie1, Fan Li1

  • 1Department of Dermatology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan, China.

Immunologic research
|August 20, 2024
PubMed
概括

与埃普斯坦-巴尔病毒 (EBV) 相关的T/NK细胞淋巴增殖性疾病 (EBV-T/NK-LPDs) 涉及免疫逃避. 具有EBV阳性的B细胞外体通过激活STAT3/IL-10/PD-L1通路来促进这种情况,从而导致免疫抑制的微环境.

关键词:
皮肤T细胞淋巴瘤 (CTCL)在EBV+淋巴状细胞细胞系 (LCLs) 中.与EBV相关的T/NK细胞淋巴增殖性疾病 (EBV-T/NK-LPDs)外基因组是外基因组的组成部分.免疫逃逸是一种免疫逃避.

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