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Updated: Jun 16, 2025

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特定于BRD4的PROTAC通过降低KLF5表达的调节,部分抑制基底类乳腺癌

Yanjie Kong1, Tianlong Lan2, Luzhen Wang3

  • 1Pathology Department, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.

Oncogene
|August 20, 2024
PubMed
概括

一种新型的向蛋白质分解的奇默药物 (PROTAC) 6b,专门向并降解BRD4,通过降低KLF5coprotein的调节来抑制基底样乳腺癌 (BLBC) 的生长. 这种化合物在BLBC治疗中显示出治疗潜力.

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