输入心膜内给药以实现心脏病的局部和向治疗
Yaping Xu1,2, Yan Chen3, Jun Jie Tan1
1USM-ALPS Joint Laboratory for Heart Research, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200, Kepala Batas, Pulau Pinang, Malaysia.
Journal of cardiovascular translational research
|August 20, 2024
概括
内皮心内给药为各种治疗药物提供了一个有前途的心脏输送途径,克服了系统性限制,以改善心脏修复. 这种方法在治疗心脏病方面显示出多功能性.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 生物医学工程 生物医学工程
背景情况:
- 腹腔内心给药是直接将药物输送到心脏的新兴途径.
- 它绕过全身循环,可能减少副作用并提高疗效.
- 心周的独特解剖学有助于局部药物和细胞的输送.
研究的目的:
- 对心脏内膜的解剖学和生理学进行审查,这与药物输送有关.
- 探索各种腹膜内心给药途径和技术.
- 讨论用于心脏修复的腹膜内输送的应用及其挑战.
主要方法:
- 关于腹膜内心给药研究的文献综述.
- 对影响分娩的解剖学和生理学因素的分析.
- 综合当前关于通过心脏向心脏输送治疗剂的研究.
主要成果:
- 通过心内输入,可以局部输送各种药物,如干细胞,生长因子和药物.
- 这种途径与全身性治疗相比具有优势,包括改善治疗作用.
- 这种方法适用于各种心脏病和修复策略.
结论:
- 腹腔内心给药是心脏治疗的可行和有利途径.
- 进一步的研究有望通过这种输送方法在心脏治疗方面的创新.
- 了解心周解剖学和注射途径对于成功应用至关重要.
相关概念视频
Cardiopulmonary Resuscitation IV: Pharmacological Management
149
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
149
Cardiomyopathy V: Interprofessional Care
75
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
75
Pericarditis IV: Nursing Management
121
Pericarditis, an inflammation of the pericardium, necessitates diligent nursing management to ensure effective patient care and recovery. The initial step in managing pericarditis is a comprehensive patient medical assessment.The patient reports chest pain aggravated by breathing, coughing, and swallowing, which worsens when lying supine. The pain often improves when sitting up and leaning forward. Additional symptoms may include fever, malaise, and, in severe cases, signs of heart failure.
121
Cardiac Catheterization I: Pre-Procedure Overview
329
Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
329
Pericarditis III: Medical Management
69
The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
69
Pericarditis I: Introduction
69
Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
69


