在局部复发的直肠癌手术后的术后静脉血栓栓塞
Chikako Kusunoki1, Mamoru Uemura2, Mao Osaki1
1Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita City, Osaka, 565-0871, Japan.
BMC cancer
|August 20, 2024
概括
局部复发性直肠癌 (LRRC) 的手术,包括圣体切除,显著增加了静脉血栓栓塞 (VTE) 的风险. 这一发现凸显了在这些复杂的病例中需要仔细进行静脉瘤预防的需要.
科学领域:
- 结肠直肠手术 结肠直肠手术
- 手术瘤学手术瘤学
- 血栓形成研究研究
背景情况:
- 在直肠癌切除后,局部复发是常见的挑战.
- 局部复发性直肠癌 (LRRC) 的手术可能是高度侵入性的,通常需要多器官切除.
- 静脉血栓栓塞 (VTE) 是已知的致命的术后并发症,特别是在盆腔手术后.
研究的目的:
- 评估为LRRC进行手术的患者中术后VTE的发生率和危险因素.
- 在LRRC外科手术中调查圣骨切除对静脉瘤风险的具体影响.
主要方法:
- 在2010年4月至2022年3月期间接受LRRC手术的166名患者的回顾性分析.
- 临床病理学数据的比较和VTE发病率在有和没有圣骨切除的患者之间.
- 单变量分析以确定VTE的风险因素.
主要成果:
- 在33.1%的患者中进行了圣体切除.
- 患有圣骨切除的患者中,静脉动脉突发症的发生率为9.09%,而未切除的患者中为1.8%.
- 在LRRC手术中,圣体切除被确定为VTE的重要危险因素 (p=0.047).
结论:
- 对LRRC进行手术,特别是与圣骨切除相结合时,是术后静脉瘤的重要危险因素.
- 对于为LRRC进行广泛的骨盆切除的患者,可能需要加强VTE预防策略.
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