多式成像检查,以区分视网膜静脉封闭的微血管和形态变化,在静脉内注射拉尼比祖马布 (ranibizumab) 以或没有三氨乙胺注射后进行
Nan Wang1,2, Jingling Zou3, Shengguo Li4
1Department of Ophthalmology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, China.
BMC ophthalmology
|August 20, 2024
概括
内拉尼比祖马布 (IVR) 有或没有三氨酸 (IVTA) 在视网膜静脉封闭中改善视力和斑点结构. 组合疗法 (IVR + IVTA) 在分支视网膜静脉封闭 (BRVO) 眼中显示出更好的结果.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜血管疾病 视网膜血管疾病
- 医疗成像医学成像
背景情况:
- 视网膜静脉封闭 (RVO) 是视力丧失的一个重要原因.
- 研究RVO的微血管和形态变化对于治疗至关重要.
- 多式成像技术有助于理解RVO病理生理学和治疗反应.
研究的目的:
- 评估RVO中的微血管和形态变化.
- 评估内拉尼比祖马布 (IVR) 有或没有三氨酸 (IVTA) 的疗效.
- 用多式成像来比较治疗结果.
主要方法:
- 对50名RVO.患者 (52只眼睛) 的回顾性和观察性研究.
- 对最佳校正视敏度 (BCVA),眼镜镜镜,FFA,SDOCT和OCTA的顺序评估.
- 进行了治疗前和治疗后的评估.
主要成果:
- 在CRVO和BRVO眼睛中,BCVA和黄斑结构 (骨厚度) 的显著改善.
- 经过OCTA检测,发现了骨无血管区 (FAZ) 和血管密度的显著变化.
- 组合治疗 (IVR + IVTA) 显示BCVA显著下降,但与单独IVR相比,BRVO的眼内压力 (IOP) 改善.
结论:
- IVR和IVR + IVTA都显著改善了BRVO中的视力和黄斑参数.
- 与IVTA同时进行IVR可能在特定的RVO情况下提供优势,需要进一步调查.
- 多式成像在监测RVO治疗反应方面是有效的.
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