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缺少表皮层-介质细胞过渡及其相关概念的基本理由

¹The MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Medical School of Nanjing University, 12 Xuefu Road, Pukou High-Tech Zone, Nanjing, 210061, China. caoying@nju.edu.cn.

Cell & bioscience

|August 20, 2024

概括

表皮-介质细胞过渡 (EMT) 和相关概念定义不完善,在关键发育过程中缺乏证据. 重新评估EMT的使用

科学领域:

细胞生物学细胞生物学
发展生物学发展生物学
癌症研究癌症研究

背景情况:

表皮细胞-介质细胞过渡 (EMT) 是一种细胞过程,在这种过程中,表皮细胞获得介质细胞特征.
在发育和疾病,特别是癌症中,EMT,介质细胞-表皮细胞过渡 (MET) 和内皮细胞-介质细胞过渡 (EndMT) 被认为是至关重要的.
关于EMT的定义,标记和角色存在重大差异和争议.

研究的目的:

批判性地评估EMT和相关细胞转换的既定概念和定义.
挑战EMT作为发展和病理学的驱动力量的普遍适用性.
重新审视EMT在科学研究中的意义及其在癌症进展中的作用.

主要方法:

批判性审查现有的文献和EMT的定义.
对EMT在神经峰形成等发育过程中的生物学基础和证据的分析.
将EMT特征与癌细胞的核心特性和神经干细胞的比较.

主要成果:

无论是上皮质还是介质细胞状态,以及它们的调节网络都没有明确定义.
没有普遍的EMT标记存在,排除基于单个标记的评估.
EMT不会推动胚胎介质细胞/神经的形成,是发育/病理过程的结果,而不是原因.

结论:

关于EMT的概念是基于有偏见的解释,缺乏基本的逻辑.
在癌症进展中EMT的作用被误认为是错误的;EMT的核心因素与神经干有关.
迫切需要重新评估EMT在发展,病理学和科学研究中的重要性.

关键词:

基本的理由是基本的理由.皮质状态皮质状态皮质介质酶过渡皮质介质过渡介质细胞状态介质细胞状态神经干的神经干性

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