与延长序列治疗相比,以诺普拉赞为基础的七天三重疗法作为一线杆菌治疗:一项随机对照试验
Yu-Tse Chiu1,2,3, Fu-Jen Lee2,3, Chen-Ya Kuo2,3
1Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, Taiwan.
与高剂量阿莫西西林 (VAC-7) 进行为期7天的诺普拉赞三次疗法,与对Helicobacter pylori根除的14天顺序疗法相比,效果不逊色. VAC-7表现出更好的耐受性和遵守性,支持其作为一线治疗的使用.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 与质子抑制剂相比,Vonoprazan提供了优越的酸抑制作用.
- 有限的数据存在于基于vonoprazan的三重治疗与一线H. pylori根除的标准治疗相比.
- 这项研究比较了基于vonoprazan的7天的三重治疗与高剂量阿莫西西林 (VAC-7) 与14天的延长序列治疗 (S-14).
研究的目的:
- 为了比较VAC-7与S-14的疗效,作为H. pylori感染的第一线治疗.
- 评估根除率,不良事件和患者在两种治疗方案之间遵守的情况.
主要方法:
- 一个单一中心前性随机对照试验,具有非劣势设计.
- 628名已确诊的H.pylori感染的成年患者被随机分配到VAC-7或S-14中.
- 根除率通过尿素呼吸试验进行评估;不良影响和合规性使用问卷进行评估.
主要成果:
- 每个方案的根除率为VAC-7的88.6%和S-14的90.3%;治疗意向率分别为81.8%和81.4%.
- 在治疗意图分析中,VAC-7被发现与S-14无差.
- 与S-14组相比,VAC-7组报告的不良事件 (恶心,厌食,头,疲劳) 较少,合规性更高 (94%).
结论:
- 与高剂量阿莫西西林一起进行为期7天的诺普拉赞三重疗法是H. pylori感染的可行和有效的第一线治疗方法.
- VAC-7疗法提供了与S-14相似的疗效,具有更好的耐受性和遵守性.
- 这些发现支持采用VAC-7作为标准的第一线H. pylori治疗.
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