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甲与甲:大规模肺栓塞 (TACO-PE) 中出血结果的比较
Jacquelyn Crawford1, Austin Roe1, Jessica Brumit1
1Department of Pharmacy, Johnson City Medical Center, Johnson City, TN, USA.
The Annals of pharmacotherapy
|August 21, 2024
概括
与alteplase相比,tenecteplase可能会增加大量肺栓塞 (PE) 患者的出血风险. 这项研究发现,在治疗PE的tenecteplase治疗患者中,出血事件的发生率更高.
科学领域:
- 心脏病学 心脏病学
- 肺部医学 肺部医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 血栓溶解对于大规模的肺栓塞 (PE) 重灌至关重要,但会带来出血风险.
- 在2022年10月,丁氏甲被采用为配方血栓解压剂.
- 现有的文献缺乏关于tenecteplase在大量PE中的出血风险和与alteplase的直接比较的明确性.
研究的目的:
- 为了比较大量PE患者中基和高高之间出血的发生率.
- 评估安全结果,包括大出血,内出血和死亡率.
主要方法:
- 追溯性,观察性队列研究.
- 包括在治疗大规模PE的成人患者中接受基或基的患者.
- 主要结局:严重出血 (ISTH标准);次要结局:有症状的ICH,住院死亡率,输血需要,住院时间.
主要成果:
- 24名患者接受了丁,20名患者接受了高高.
- 血流发生在17%的丁氏甲患者和5%的高氏甲患者中.
- 症状性ICH发生在1名白血素患者中;两人需要大规模输血协议.
结论:
- 结果表明,在大规模PE中,有潜在的担忧,即与太尼克特等剂增加的出血率.
- 需要使用更大的样本大小进行进一步的研究来证实这些发现.
- 这一比较为大量PE中使用tenecteplase提供了初步的安全见解.
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