在肥胖个体中,联合风险因素控制程度和发生慢性病的程度
Rui Tang1, Minghao Kou1, Xiang Li1
1Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.
Diabetes, obesity & metabolism
|August 21, 2024
概括
管理多种风险因素可显著降低肥胖个体慢性病 (CKD) 的风险. 控制所有六个关键因素可以将CKD风险降低49%,中和与肥胖有关的过度风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 肥胖是慢性病 (CKD) 的重要危险因素.
- 管理可修改的风险因素对于预防CKD进展至关重要.
- 联合风险因素控制对肥胖中CKD风险的影响需要进一步调查.
研究的目的:
- 确定控制多种风险因素是否可以降低肥胖个体中CKD风险的增加.
- 量化风险因素控制程度与肥胖参与者的CKD发病率之间的关联.
主要方法:
- 英国生物银行的一项队列研究包括超过97,000名肥胖参与者,并与正常体重对照进行了匹配.
- 评估了六个主要的CKD风险因素 (血压,糖化血红蛋白,LDL胆固醇,白蛋白尿,吸烟,体力活动).
- 考克斯的比例危险模型分析了风险因素控制与CKD风险之间的关联.
主要成果:
- 每一个额外的受控风险因素,在肥胖个体中,每一个额外的受控风险因素都将CKD风险降低11%.
- 控制所有六个风险因素可以将CKD风险降低49%,并抵消与肥胖相关的过度风险.
- 保护作用在男性,健康食品得分较低的男性和糖尿病药物使用者中更为明显.
结论:
- 联合风险因素控制表明,肥胖症与CKD风险的累积反向关联.
- 实现对多种风险因素的最佳控制可以有效地减轻与肥胖相关的CKD风险增加.
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