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Updated: Jun 16, 2025

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淋巴毒素β激活的LTBR/NIK/RELB轴驱动胆管癌的扩散

Kaiyu Xu1,2,3, Annika Kessler1,2,4, Federico Nichetti5,6

  • 1Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg University Hospital, Heidelberg, Germany.

Liver international : official journal of the International Association for the Study of the Liver
|August 21, 2024
PubMed
概括

非正规的NF-κB (激活B细胞的核因子卡帕-光链增强器) 途径,特别是淋巴毒素-β/NF-κB诱导激酶/RelB轴,驱动胆管癌的生长. 抑制这种途径为这种侵袭性癌症提供了潜在的治疗策略.

关键词:
在LTB中,LTB是LTB.在 NF-κBB 中.尼克尼克尼克是什么意思在RelB上,RelB就是RelB.胆瘤是一种胆瘤.小分子抑制剂 B02222

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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