使用细胞病理学的口腔癌查:使用贝塞斯达分类的先进提案
Tatiana Wannmacher Lepper1, Renata Ferreira Prigol1, Ana Laura Ferrares Espinosa1
1Dental School - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
概括
使用Papanicolaou染色的口腔癌查显示了口腔状细胞癌的高准确性. 定量和细胞形态测量分析可以改善风险分类,用于早期检测口腔恶性瘤.
科学领域:
- 口腔病理学 口腔病理学
- 细胞病理学 细胞病理学
- 癌症查 癌症查
背景情况:
- 早期发现口腔癌至关重要,需要方法来识别临床前变化.
- 口腔细胞病理学已经证明了作为查工具的潜力.
- 本研究评估了Papanicolaou染色用于口腔癌查中的定性和定量分析.
研究的目的:
- 评估Papanicolaou染色在口腔癌查中的有效性.
- 进行口腔细胞病理学的定性定量分析.
- 在口腔癌查中确定风险分类的客观标准.
主要方法:
- 从四个组收集口腔涂抹:对照组,暴露于致癌物质的,潜在的恶性疾病 (带有和没有发育不良) 和口腔状细胞癌.
- 帕帕尼科劳染色被用于细胞学分析.
- 对来自143个个体的8100张图像进行了定性,定量和细胞形态测量分析.
主要成果:
- 帕帕尼科劳染色在识别口腔状细胞癌时实现了100%的准确性.
- 定量分析显示,在潜在的恶性疾病和口腔状细胞癌中,细胞类型的比例不同.
- 细胞形状测量分析显示,口腔状细胞癌中核/细胞质比较高,值为17%,表明精度提高.
结论:
- 乳腺癌染色,结合定量和细胞形态测量分析,可以显著改善口腔癌查.
- 可以将客观标准整合到修改后的贝塞斯达口腔风险分类系统中.
- 这种方法提高了口腔癌查方法的准确性和有效性.
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