晚期嗅觉神经母细胞瘤内切除后的生存分析和预后因素:一个单一机构的经验
Xiaole Song1,2, Jingyi Yang1, Cuncun Yuan3
1ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
概括
结合放射治疗和化疗的内镜手术对晚期嗅觉神经母细胞瘤 (ONB) 有效. 关键的预后因素包括避免并发症,实现全面切除,以及术后放射治疗对生存的重要性.
科学领域:
- 神经外科 神经外科
- 在瘤学瘤学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 嗅觉神经母细胞瘤 (ONB) 是一种罕见的恶性瘤,起源于嗅觉上皮.
- 先进的阶段往往涉及到广泛的局部入侵,造成手术挑战.
研究的目的:
- 为了确定患有晚期嗅觉神经母细胞瘤 (ONB) 的患者进行内镜外科切除的预后因素.
- 评估内镜手术与辅助疗法相结合的疗效和安全性.
主要方法:
- 对85名经过内镜切除的病理证明ONB患者的回顾性审查.
- 对临床病理学数据,治疗细节,并发症和结果的分析.
- 卡普兰-梅尔生存分析和考克斯回归建模以确定预后因素.
主要成果:
- 五年总生存率 (OS) 和无病生存率 (DFS) 分别为83.7%和74.9%.
- 骨头骨基切除与改善的OS相关 (100%与77.5%相比).
- 生存的独立预后预测因素包括外科手术期间的并发症,总体切除,轨道入侵,术后放射治疗和骨骨基切除.
结论:
- 内镜手术,放射治疗和化疗为高级ONB提供了有效和安全的治疗方法.
- 术后放射治疗对于改善OS和DFS至关重要.
- 由于潜在的并发症与生存益处,应仔细考虑杜拉切除.
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