四项的PRECISE-DAPT评分识别了冠状动脉旁路移植患者的冠状动脉旁路移植,这些患者有更高的风险出现出院后严重出血
Philip Enström1,2, Andreas Martinsson2,3, Mary Rezk1,2
1Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg 41345, Sweden.
European heart journal. Cardiovascular pharmacotherapy
|August 21, 2024
概括
在冠状动脉旁路移植 (CABG) 后的患者中,PRECISE-DAPT得分适度地识别出主要出血风险. 这一分数有助于个性化抗血栓治疗,以改善患者的治疗结果.
科学领域:
- 心脏病学 心脏病学
- 血管外科 血管外科
- 药理学 药理学是指药理学的学科.
背景情况:
- 早期识别出血风险对于定制抗血栓治疗至关重要.
- PRECISE-DAPT评分是为了评估皮肤冠状动脉干预 (PCI) 患者出血风险而开发的.
- 在冠状动脉旁路移植 (CABG) 患者中需要验证.
研究的目的:
- 为了验证PRECISE-DAPT得分用于估计CABG后患者的出血风险.
- 评估评分的准确性,以识别出院后患大出血高风险的患者.
主要方法:
- 分析了一组在瑞典 (2009-2020年) 隔离的CABG患者的队列,这些患者在出院后幸存下来.
- 在双重抗血小板治疗 (DAPT) 或单一治疗的患者中计算了四项PRECISE-DAPT得分.
- 严重出血被定义为因出血而入院;使用C统计和考克斯回归来评估相关性.
主要成果:
- 1.9%的DAPT患者和1.3%的单一治疗患者在出院后的第一年内发生严重出血.
- 在PRECISE-DAPT得分中,32.9%的DAPT患者和38.2%的单一治疗患者被确定为高出血风险.
- 在ROC曲线下的面积为DAPT的0.67和单一治疗的0.71,具有高出血风险的显著危险比率.
结论:
- PRECISE-DAPT评分在识别CABG后重大出血风险方面表现出适度的准确性.
- 在CABG患者中,得分的预测性能与在PCI患者中观察到的可比.
- 这一验证证实了PRECISE-DAPT得分对CABG患者风险分层的潜在使用.
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