炎症性肠病与霍奇金淋巴瘤或多发性硬化症之间的流行病学关联
Amnon Sonnenberg1,2, Ruth Kohen3
1Section of Gastroenterology, Portland VA Medical Center, Portland, Oregon.
Gastro hep advances
|August 21, 2024
概括
霍奇金淋巴瘤 (HL) 和多发性硬化症 (MS) 与炎症性肠道疾病 (IBD) 共享风险因素,包括克罗恩病 (CD) 和性结肠炎 (UC). 地理和患者数据显示,这些情况经常同时发生,这表明有共同的潜在原因.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 神经学 神经学
- 胃肠病学 胃肠病学
背景情况:
- 流行病学研究表明,霍奇金淋巴瘤 (HL),多发性硬化症 (MS),克罗恩病 (CD) 和性结肠炎 (UC) 的共同危险因素.
- 这种共同的病因表明,这些不同疾病的地理分布和患者共同发生的潜在相似之处.
研究的目的:
- 调查美国各州HL,MS,CD和UC之间的地理相关性.
- 为了确定患者是否更有可能同时诊断出HL,MS,CD或UC,而不是偶然预期的.
主要方法:
- 一项横截面研究分析了医疗保险和医疗补助服务中心 (CMS) 人口中HL,MS,CD和UC的频率 (2018年).
- 通过统计相关性分析评估了四种诊断之间的地理相关性.
- 一项病例控制研究将任何两种诊断的观察到的同时发生与预期的频率进行了比较,使用几率比率和95%置信区间.
主要成果:
- 在四种疾病 (HL,MS,CD,UC) 的所有对之间发现了显著的正相关性,相关系数 (r) 从0.46到0.72不等 (P < .001).
- 炎症性肠病 (IBD) 与同时出现的HL (OR:1.22,95%CI:1.01-1.48) 和MS (OR:1.35,95%CI:1.25-1.46) 显著相关.
- 该研究分析了来自6,462,321名独特的CMS患者的数据,确定了8027名HL患者,42,934名MS患者,40,623名CD患者,32,521名UC患者.
结论:
- 观察到的IBD和HL或MS之间的流行病学关联表明它们的病因或发病过程中存在潜在的共同途径.
- 这些发现支持了影响这些疾病的分布和同时发生的共同风险因素的假设.
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