治疗模式和持续性疾病活动在患有乙性食道炎的患者:一个回顾性队列研究
Olulade Ayodele1, Rohan C Parikh2, Elizabeth Esterberg2
1Takeda Development Center Americas, Inc, Lexington, Massachusetts.
Gastro hep advances
|August 21, 2024
概括
性食道炎 (EOE) 患者面临着具有挑战性的治疗旅程和所有年龄组的重大疾病负担. 现实世界的数据显示,尽管治疗,但症状和医疗保健需求仍然存在.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 现实世界的证据研究研究.
背景情况:
- 有限的现实世界的数据存在于患者的旅程和疾病负担的异性食道炎 (EOE) 在非三级护理设置.
- 了解不同年龄组的EoE患者体验对于改善护理至关重要.
研究的目的:
- 收集和分析真实世界的数据,以性食道炎 (EOE) 患者的旅程和疾病负担.
- 调查儿童,青少年,成年人和老年人群的EoE患者体验.
主要方法:
- 现实世界的回顾性队列研究,利用美国医疗保健系统的电子病历和索赔数据.
- 纳入标准:≥2次EoE诊断 (2009-2018),≥1次内镜检查,以及≥12个月的前/后指数数据.
- 分析包括临床发现,医疗资源利用,专家咨询,疗法和疾病进展标志物.
主要成果:
- 招募了613名患者,182名儿童,146名青少年,244名成年人,41名老年人.
- 尽管索引后初始内镜和组织学改善,但异常发现在3年内仍然存在 (62.3%内镜,51.2%组织学).
- 医疗保健的高利用率,专家咨询 (86.3%) 和停止治疗 (44.0%) 是常见的;13.9%的患者患有疾病进展.
结论:
- 患有乙性食道炎 (EoE) 的患者经历了艰难的治疗旅程和相当大的疾病负担,无论年龄如何.
- 现实世界的证据凸显了管理EdE的持续挑战以及改善治疗策略的需要.
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