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在绝经后妇女中开发和验证预测MAFLD风险的预测名录

Ming Yang^1,2, Xingyu Chen², Qiaohui Shen¹

¹College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.

Frontiers in endocrinology

|August 21, 2024

概括

这项研究开发了一种预测性名谱,以识别使用简单的临床和实验室数据的代谢相关脂肪肝疾病 (MAFLD) 风险的绝经后妇女. 该模型有助于在这个高危人群中早期评估MAFLD的风险.

科学领域:

肝病学肝病学是一种肝病学.
内分泌学在内分泌学.
公共卫生公共卫生

背景情况:

与代谢相关的脂肪肝疾病 (MAFLD) 是一个日益严重的健康问题.
绝经后的妇女是MAFLD发展的高风险人口.
早期识别和干预对于在这个人群中管理MAFLD至关重要.

研究的目的:

在绝经后妇女中建立一个对MAFLD风险的预测性诺莫格拉姆模型.
利用随时可用的临床和实验室指标,以提高临床效用.
为了促进MAFLD的早期风险分层和干预.

主要方法:

从942名绝经后妇女回顾性数据收集 (2023年1月至10月).
分为培训 (676个案例) 和验证 (226个案例) 队列.
通过逻辑和逐步回归分析识别显著的MAFLD预测因子.

主要成果:

确定了MAFLD的11个关键预测因素,包括职业,BMI,腰比,堕胎史,焦虑,高血压,高脂血症,糖尿病,高尿血和饮食.
诺米图表表现出强大的预测性能,训练组的C指数为0.827,验证组的C指数为0.787.
曲线下的面积 (AUC) 值为0.827 (培训) 和0.787 (验证),通过决策曲线分析 (DCA) 显示了良好的校准和净收益.

结论:

在绝经后妇女中成功开发了一种对MAFLD进行验证的预测性名谱.
诺米图有效地协助临床医生在早期MAFLD风险评估.
该工具支持对处于风险的绝经后个体的及时干预策略.

关键词:

马夫尔德 (MAFLD) 是一个这个名字是名ogramogram.绝经后的妇女绝经后的妇女预测模型是一个预测模型.有关风险因素的风险因素.

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