代谢性肥胖现象与患前列腺癌的风险之间的关联:基于新疆的倾向性得分匹配研究
Jinru Wang1, Aireti Apizi2, Hao Qiu1
1School of Public Health, Xinjiang Medical University, Urumqi, China.
Frontiers in endocrinology
|August 21, 2024
概括
与代谢健康的非肥胖相比,代谢健康的肥胖 (MHO) 和代谢不健康的肥胖 (MUO) 显著增加前列腺癌 (PCa) 风险. 这些发现突出了肥胖现象型作为PCa发展的关键因素.
科学领域:
- 在瘤学瘤学.
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 与肥胖相关的代谢功能障碍与癌症风险增加有关.
- 代谢性肥胖表型与前列腺癌 (PCa) 之间的特定关联需要进一步澄清.
研究的目的:
- 研究不同代谢肥胖现象型与患前列腺癌的风险之间的关系.
- 确定导致前列腺癌发展的特定代谢风险因素.
主要方法:
- 将参与者分为四种代谢性肥胖表型:代谢上健康的非肥胖 (MHNO),代谢上健康的肥胖 (MHO),代谢上不健康的非肥胖 (MUNO) 和代谢上不健康的肥胖 (MUO).
- 适用倾向性得分匹配用于控制的混变量.
- 使用单变量和多变量条件后勤回归分析来评估代谢肥胖现象型,代谢风险因素和PCa发生率之间的关联.
主要成果:
- 与MHNO相比,代谢健康肥胖 (MHO) 个体的PCa风险是MHNO的2.166倍.
- 与MHNO相比,代谢不健康的肥胖 (MUO) 个体的PCa风险是MHNO的2.398倍.
- 高血糖症,高甘油三和有三种或更多的代谢风险因素也与PCa风险增加有关.
结论:
- 代谢健康的肥胖 (MHO) 和代谢不健康的肥胖 (MUO) 都与患前列腺癌的风险明显增加有关.
- 代谢性肥胖现象型是前列腺癌风险评估的关键指标.
更多相关视频
06:55Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
14.4K
06:04Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
831
相关概念视频
Obesity
416
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
416
Genome-wide Association Studies-GWAS
13.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.2K
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
Cholesterol: Significance and Regulation
523
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
523
