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巴西患有质瘤的儿科患者:治疗特征和生存结果
Maria Thereza Mansur Starling1, Allan Andresson Lima Pereira2, Gustavo Viani Arruda3,4
1Department of Radiation Oncology, Hospital Sírio-Libanês, São Paulo, Brazil.
概括
巴西的儿科质瘤显示出不同的生存率,低度类型具有有利的结果. 质母细胞瘤和脑干质母细胞瘤表明,儿童癌症患者的整体存活率 (OS) 最差.
科学领域:
- 儿科瘤学 儿科瘤学
- 神经瘤学神经瘤学
- 流行病学 流行病学
背景情况:
- 儿科质瘤是儿童癌症的一个重大挑战.
- 了解生存率对于治疗计划和预后至关重要.
研究的目的:
- 为了确定巴西儿科质瘤的总生存率 (OS).
- 分析年龄,瘤部位和治疗对OS的影响.
- 使用基于人口的国家数据库进行全面分析.
主要方法:
- 利用圣保罗科中心基金会的公共数据库进行患者识别 (1999-2020).
- 包括1296名被诊断为儿童中枢神经系统 (CNS) 质瘤的患者.
- 用Kaplan-Meier和日志等级测试进行生存分析.
主要成果:
- 最常见的是质母细胞瘤 (38.27%) 和皮洛细胞性星系细胞瘤 (32.87%).
- 脑干瘤与明显更糟糕的生存状况相关 (p = 0.001).
- 综合治疗 (手术,放射治疗,化疗) 与较少强化治疗相比,平均存活时间 (20 个月) 更高.
结论:
- 低度儿科质瘤显示出良好的预后.
- 质母细胞瘤和脑干质母细胞瘤与最贫穷的生存系统有关.
- 高度质瘤的治疗减强与巴西的生存率下降有关.
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