转移性结直肠癌中的免疫疗法诱导的肝炎:系统性审查和元分析
Sakditad Saowapa1, Natchaya Polpichai2, Manasawee Tanariyakul3
1Department of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
Proceedings (Baylor University. Medical Center)
|August 21, 2024
概括
免疫检查点抑制剂 (ICI) 在转移性结直肠癌患者中显示出类似的肝炎风险. 原始治疗的患者面临着这种与免疫相关的不良事件的更高发病率.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 用免疫检查点抑制剂 (ICI) 进行的免疫疗法推进了癌症治疗.
- 免疫相关的不良事件 (irAEs),包括肝炎,是ICI治疗日益关注的问题.
- 在癌症患者中,肝炎可能需要停止治疗.
研究的目的:
- 评估转移性结直肠癌 (mCRC) 患者接受各种ICI疗法的肝炎患病率.
- 为了比较不同ICI治疗方案 (PD-1,PDL-1,组合疗法) 的肝炎发病率.
主要方法:
- 在PubMed,PubMed Central和Google Scholar的系统文献搜索,截至2023年11月.
- 在严格的排除标准应用后,包括了五项相关研究.
- 使用全面的元分析软件对提取的数据进行元分析.
主要成果:
- 肝炎发病率在PD-1单疗法 (2.6%),PDL-1单疗法 (2.2%) 和PD-1/CTLA-4组合疗法 (1.7%) 之间是可比的.
- 3级以上肝炎的发病率也相似:2.1% (PD-1),2.2% (PDL-1) 和1.7% (组合).
- 与先前接受治疗的患者相比,天真治疗的mCRC患者的肝炎发病率较高 (3.2%任何等级,2.6%等级≥3) (1.6%任何等级,1.6%等级≥3).
结论:
- 在mCRC患者的不同ICI疗法中,肝炎的风险相似.
- 在未接受治疗的mCRC患者中,肝炎的发病率较高.
- 在接受ICI治疗的mCRC患者中,对肝炎的监测至关重要,特别是在未经治疗的个体中.
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