共同感染与COVID-19变种之间结果差异的关联
Christian Beltran1, Jennifer Hood1, Valerie Danesh2,3,4
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Baylor Scott & White Medical Center - Temple, Temple, Texas, USA.
细菌共感染增加了所有变种的住院COVID-19患者的死亡率. 与Alpha和Omicron激增相比,Delta变种的激增显示出明显更糟糕的30天和90天死亡率.
科学领域:
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
- 流行病学 流行病学
背景情况:
- 已知二次细菌共感染会增加COVID-19患者的死亡率.
- 之前没有任何研究专门研究了共感染对不同COVID-19变体 (Alpha,Delta,Omicron) 结果的影响.
研究的目的:
- 调查不同COVID-19变种住院患者的细菌共感染和死亡结果之间的关联.
- 为了比较 coinfections 在阿尔法,三角形和Omicron 变种激增期间对死亡率的影响.
主要方法:
- 一项对21186名住院COVID-19患者的观察性队列研究,涉及Alpha,Delta和Omicron变种的激增.
- 数据是通过病毒性呼吸道疾病普世研究COVID-19注册表 (NCT04323787) 从电子健康记录中收集的.
- 多变量考克斯比例危险回归用于评估冲浪时期对死亡率的调整后影响.
主要成果:
- 细菌共感染率为8.5% (阿尔法),11.7% (三角形) 和11.9% (俄米克朗).
- 与孤立的COVID-19相比,共感染与所有变种的30天和90天死亡率更高有关.
- 与阿尔法和Omicron激增相比,在三角洲激增期间的死亡率明显更差.
结论:
- 细菌共感染与所有COVID-19变种住院患者的死亡率增加有关.
- 德尔塔变种的激增与较高的风险调整后死亡率有关,特别是当共感染存在时.
更多相关视频
12:21A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
Published on: September 28, 2022
08:48Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
Published on: February 16, 2022
相关概念视频
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Viral Recombination
Single Nucleotide Polymorphisms-SNPs
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
Viral Mutations
Confounding in Epidemiological Studies
