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Cingulate sulcus标志:脑小血管疾病人口中的描述性分析

Weishuai Li¹, Chang Su¹, Zhihan Wang¹

¹Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

Frontiers in aging neuroscience

|August 21, 2024

概括

带标志 (CSS) 在26%的大脑小血管疾病 (CSVD) 患者中存在,与较低的认知功能和特定的MRI标志物相关. 这表明CSS可能表明各种CSVD机制和流体静止.

科学领域:

神经学神经学
放射学放射学是一门学科.
脑血管疾病脑血管疾病

背景情况:

环状标志 (CSS) 与异常性正常压力水头 (iNPH) 有关,表明潜在的脑脊液 (CSF) 循环问题和淋巴系统损害.
大脑小血管疾病 (CSVD) 与iNPH具有共同的潜在机制,但CSS和CSVD之间的关系尚不清楚.

研究的目的:

研究被诊断患有大脑小血管疾病 (CSVD) 的患者中带带状硫标志 (CSS) 的患病率.
在CSVD的背景下探索CSS的潜在机制和协会.

主要方法:

追溯收集308名CSVD患者的数据 (2020年1月 - 2022年10月).
使用迷你精神状态检查 (MMSE) 评估全球认知功能.
对四种CSVD磁共振成像 (MRI) 标记物的评估:白质高强度 (WMH),大脑微血流 (CMB),缺口,扩大周血管空间 (EPVS),以及CSS和埃文斯指数 (EI).

主要成果:

在308名患者中,80名患者 (26%) 检测到了CSS.
与没有CSS的患者相比,患有CSS的患者的MMSE得分明显较低 (p < 0.001).
多变量分析显示,CSS和缺口 (OR 0.358) 之间存在独立的相关性,叶片主导的CMB (OR 2.683),周周结膜WMH Fazekas得分 (OR 1.693) 和EI (OR 1.276).

结论:

带带状标志 (CSS) 在脑小血管疾病 (CSVD) 患者的一个子组中可观察到.
在CSVD中存在CSS可能意味着不同的致病机制.
在CSVD患者中,CSS可以反映不同程度的脑脊液 (CSF) /间歇液 (ISF) 停滞.

关键词:

大脑微型出血.大脑小血管疾病是大脑小血管疾病.带带状的硫标志带带的硫标志淋巴系统淋巴系统白质病变 - 白质病变的病变

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