在儿童和青少年住院治疗环境中使用非典型抗精神病药物的安全性:自然主义研究
Hüseyin Burak Baykara1, Sevay Alşen Güney1, Sibelnur Avcil2
1Department of Child and Adolescent Psychiatry, Dokuz Eylül University, Faculty of Medicine, Izmir, Türkiye.
Psychiatry and clinical psychopharmacology
|August 21, 2024
概括
非典型抗精神病药 (AAP) 对儿童和青少年构成风险,可能导致代谢和血液学问题. 在儿童患者开始AAP治疗之前,仔细评估风险和益处至关重要.
科学领域:
- 儿科精神病学 儿科精神病学
- 药理学 药理学是指药理学的学科.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 非典型抗精神病药 (AAP) 经常被处方给患有精神疾病的儿童和青少年.
- 对于AAPs在该人群中的代谢,血液学和内分泌学不良影响存在担忧.
研究的目的:
- 研究AAPs对儿科住院患者的代谢,血液和内分泌系统的不良影响.
- 评估与AAP单一治疗相关的体重,葡萄糖,脂质概况和益生菌水平的变化.
主要方法:
- 对208名接受AAP单一治疗的儿童和青少年进行了回顾性分析.
- 收集了关于体重,BMI,BMI z-score,禁食血糖,脂质概况,全血细胞计,肝功能,甲状腺功能和益乳素水平的数据.
- 使用儿童全球评估尺度 (CGAS) 和国家儿童和青少年健康结果尺度 (HoNOSCA) 进行功能评估.
主要成果:
- 与Risperidone (RIS),Quetiapine (QUE) 和Aripiprazole (ARI) 组相比,olanzapine (OLA) 组的BMI和BMI z-score显著增加,这与risperidone (RIS),quetiapine (QUE) 和aripiprazole (ARI) 组相比显著增加.
- 与RIS组相比,OLA组观察到空腹血糖 (FBG) 的显著增加.
- 在不同AAP组中发现了三糖水平的统计学上显著差异.
结论:
- 接受AAP的儿科患者面临高血清素,体重增加和代谢/血液学障碍的显著风险.
- 在AAP治疗之前和治疗期间,临床医生与患者和家人一起进行彻底的风险益处评估至关重要.
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