全癌症分析显示,GGPS1在多种瘤类型的瘤发生中起着重要作用
1School of Marine and Biological Engineering, Yancheng Teachers University, Yancheng, Jiangsu, China.
Heliyon
|August 21, 2024
概括
格拉尼尔格拉尼尔二酸合成酶1 (GGPS1) 在多种癌症中被上调,与预后不佳相关,并与癌症相关的纤维细胞相关. GGPS1可能促进瘤形成并影响新陈代谢途径.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 基拉尼尔基拉尼尔二酸盐合成酶1 (GGPS1) 的抑制会影响细胞增殖.
- 新出现的证据表明GGPS1与癌症之间存在联系,但缺乏全面的泛癌症分析.
研究的目的:
- 研究GGPS1在各种癌症类型的瘤发生中的作用.
- 在泛癌背景下分析GGPS1表达,遗传变化和预后意义.
主要方法:
- 利用癌症基因组图谱 (TCGA) 数据库进行人类临床数据分析.
- 检查了GGPS1RNA和蛋白质表达水平.
- 评估了包括放大在内的遗传改变.
- 与患者预后和癌症相关纤维细胞 (CAF) 透相关联的GGPS1表达.
- 进行了GGPS1相互作用和相关基因的功能丰富分析.
主要成果:
- 在RNA和蛋白质水平上,GGPS1在多种癌症中显著上调,特别是在乳腺癌 (BRCA),肝细胞癌 (LIHC/HCC) 和肺腺癌 (LUAD) 中.
- 基因放大是BRCA,卵巢瘤和HCC中占主导地位的遗传改变.
- 升高的GGPS1表达与患者预后较差以及包括LIHC在内的几种癌症的整体存活率相关.
- GGPS1表达与BRCA和LUAD中的CAF透有关.
- 功能性丰富性分析显示,它参与了类骨干生物合成,类固醇生物合成和代谢途径.
结论:
- GGPS1在促进瘤发生和瘤进展方面发挥着潜在的作用,特别是在BRCA和LUAD中.
- GGPS1与类固醇生物合成和代谢途径有关.
- 进一步研究GGPS1在癌症中的功能是有必要的.
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