怀孕间隔和不良产周结局:个体内比较方法
Maria Sevoyan1, Marco Geraci1,2, Edward A Frongillo3
1Department of Epidemiology and Biostatistics Arnold School of Public Health, University of South Carolina Columbia South Carolina USA.
Health science reports
|August 21, 2024
概括
短暂的妊娠间隔 (IPI) 并没有增加早产,怀孕年龄小,出生体重低或NICU入院的风险. 然而,24个月或更长的IPI与低出生体重的更高几率有关.
科学领域:
- 生殖流行病学 生殖流行病学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 围产期健康 围产期健康
背景情况:
- 之前关于妊娠间隔 (IPI) 和围产期结局的研究使用了个体间方法,可能被未测量的母因子所混.
- 这项研究采用了个体内分析,以提供对IPI与产前期结局关联的更全面的检查.
研究的目的:
- 通过个人内部比较分析,研究妊娠间隔 (IPI) 和不良周产期结局之间的关联.
- 为了减轻因未测量的,时间不变的母性特征而引起的混.
主要方法:
- 利用了来自NICHD连续怀孕研究的10,647名至少有3个活产单胎怀孕的个体的数据.
- 采用条件后勤回归,每个人匹配两个IPI,并根据个人内部的因素进行调整.
- 检查的结果包括早产 (PTB),怀孕年龄小 (SGA),低出生体重 (LBW) 和NICU入院.
主要成果:
- 与18-23个月的参考间隔相比,IPI <6个月时没有观察到PTB,SGA,LBW或NICU入院的几率显著增加.
- 6-11个月和12-18个月的IPI也没有明确的关联与增加不良结果的几率.
- 妊娠间隔≥24个月与分娩低出生体重婴儿的几率增加有关.
结论:
- 个体内分析没有支持短暂的妊娠间隔 (<6个月) 与不良围产期结局的几率增加之间的关联.
- 较长的妊娠间隔 (≥24个月) 与低出生体重的可能性更高有关.
- 这些发现强调了考虑IPI对特定围产期结果影响的方向性的重要性.
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