不同代谢肥胖现象与侵蚀性食道炎之间的关联:一项回顾性研究
Tao He1,2, Xiao-Yu Sun1,2, Meng-Han Tong1,2
1Department of Gastroenterology, the First Affiliated Hospital of Dalian Medical University, Dalian, People's Republic of China.
Diabetes, metabolic syndrome and obesity : targets and therapy
|August 21, 2024
概括
代谢不健康的肥胖显著增加侵蚀性食道炎 (EE) 的风险,肥胖的影响比单独的代谢障碍更大. 干预措施应解决这两种条件,以减轻EE风险.
科学领域:
- 胃肠病学 胃肠病学
- 代谢健康 代谢健康
- 肥胖问题研究研究
背景情况:
- 肥胖与侵蚀性食道炎 (EE) 的风险增加有关.
- 代谢异常是EE发展的关键因素.
- 了解代谢性肥胖现象型对于评估EE风险至关重要.
研究的目的:
- 评估不同代谢肥胖现象类型与发展EE的风险之间的关联.
- 调查与代谢性肥胖和EE相关的性别和年龄特定风险.
主要方法:
- 对11599名接受上部胃肠内镜检查的受试者的回顾性研究.
- 将其分为四组:代谢健康的非肥胖 (MHNO),代谢健康的肥胖 (MHO),代谢不健康的非肥胖 (MUNO) 和代谢不健康的肥胖 (MUO).
- 多变量逻辑回归分析以确定表型与EE风险之间的关系.
主要成果:
- MUNO,MHO和MUO组显示出比MHNO组更高的EE风险.
- MUO组具有最高的EE风险 (ORs:男性5.473,女性7.566).
- 随着代谢风险因素的比例而增加EE风险;肥胖显示出比代谢障碍更强大的影响.
结论:
- 代谢障碍和肥胖都会增加EE的风险,肥胖是一个更重要的因素.
- 临床策略应针对肥胖和代谢异常,以减少EE的发生率.
- 识别特定的代谢性肥胖现象型可以为EE的有针对性的预防和治疗方法提供信息.
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