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相关概念视频

Oogenesis02:07

Oogenesis

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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
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饮用水质量会影响卵细胞活力和胚胎发育.

Yasmyn E Winstanley1, Macarena B Gonzalez1, Eryk Andreas1

  • 1Robinson Research Institute, School of Biomedicine, The University of Adelaide, Adelaide, SA, Australia.

Frontiers in reproductive health
|August 21, 2024
PubMed
概括

饮用水中的环境毒素可能会损害生育能力. 研究表明,自来水中的Per和Poly-fluoroalkyl物质 (PFAS) 导致雌性小鼠的胚胎损失和发育障碍,即使在被认为是安全的水平上也是如此.

关键词:
胚胎发育过程中的胚胎发育.环境污染物环境污染物女性生育能力女性生育能力卵子细胞 卵子细胞perfluoroalkyl 和 polyfluoroalkyl 物质 (PFAS) 的使用情况水的质量水的质量.

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科学领域:

  • 生殖毒理学 生殖毒理学
  • 环境健康 环境健康
  • 发育生物学是发展生物学.

背景情况:

  • 生殖功能是整体健康和环境中毒物暴露的敏感指标.
  • 生育能力的干扰可以表明更广泛的健康问题.
  • 水中的环境污染物对生殖健康构成风险.

研究的目的:

  • 研究饮用水源变化对雌性小鼠生殖功能的影响.
  • 为了确定对观察到的生殖功能障碍负责的有毒物质.
  • 评估Per-和多醇基物质 (PFAS) 对卵细胞和胚胎发育的影响.

主要方法:

  • 雌性小鼠暴露在不同的自来水源和PFAS污染水中.
  • 评估卵细胞质量,介质成熟和胚胎发育.
  • 分析水中的污染物成分,包括微量元素,酸盐和PFAS.
  • PFAS度与生殖参数之间的相关性分析.

主要成果:

  • 在雌性小鼠中,切换饮用水源导致胚胎损失和卵细胞成熟受损.
  • 污染水源的碳过可以扭转有害影响.
  • 在受污染的水中检测到Per-和Poly-fluoroalkyl物质 (PFAS),大约为4 ng/L.
  • 接触PFAS污染水 (0.64.4 ng/L) 导致卵细胞质量下降,胚胎发生障碍,胚胎细胞数量减少.
  • PFAS度与卵细胞活力有负相关.

结论:

  • 龙头水,即使在目前的安全指南中,也可能含有有害于哺乳动物胚胎发育的污染物.
  • 和多醇基物质 (PFAS) 可能是观察到的生殖毒性的原因.
  • 需要进一步的研究来确认PFAS是致病原体,并确定安全的暴露水平.
  • 调查结果对公共卫生和水质政策产生重大影响,这些政策涉及环境毒素和生殖健康.