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相关概念视频

In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...

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Updated: May 10, 2026

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery
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将液体栓塞剂的可视化性能与使用新型可注射幻影的液体栓塞剂进行比较.

J Ryan Mason1, Cristina Dodge2, Adam Beardsley3

  • 1Department Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
|August 21, 2024
PubMed
概括
此摘要是机器生成的。

液体栓塞剂 (LEAs) 的辐射透明度不同,影响神经血管栓塞. 奥姆尼帕克300和NBCA提供最高的对比分辨率,对于安全有效的内血管治疗至关重要.

关键词:
神经血管栓塞是神经血管栓塞.对比分辨率对比分辨率对比度对比分辨率对比分辨率对比分辨率液体栓塞是一种液体栓塞.

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科学领域:

  • 干预性神经辐射学
  • 医疗成像医学成像
  • 生物材料科学 生物材料科学

背景情况:

  • 液体栓塞剂 (LEAs) 的有效放射可视化对于安全有效的神经血管栓塞程序至关重要.
  • 目前的LEA在放射性透明度上表现出显著的变化,可获得的比较数据有限.
  • 精确评估LEA可见性对于血管内血管治疗动脉静脉分流病变至关重要.

研究的目的:

  • 量化比较各种液体栓塞剂 (LEA) 与标准对比介质的对比分辨率 (CR).
  • 在模拟栓塞过程中使用路线图光学评估LEA可见性.
  • 在神经血管干预中建立LEA辐射透明度的比较框架.

主要方法:

  • 一种可注射血管造影仪的设计,配备并行管道 (313-1000微米).
  • 注射和分析八种放射性不透明剂:Onyx 18/34,Squid 12/18,PHIL 25%/30%,Trufill (NBCA) 和Omnipaque 300.这些药物都使用了放射性不透明剂.
  • 使用对比度与噪声比率 (CNR) 计算来评估CR.

主要成果:

  • 奥姆尼帕克300和NBCA展示了最高的对比分辨率.
  • 菲尔25%的CNR是最低的,为Omnipaque 300的45%.
  • 奥尼克斯18/34显示出更高的CNR (大约. 82%的奥姆尼帕克300) 超过鱼12/18 (52-55%).
  • 在较小的容器直径 (70%在500微米,90%在313微米) 中观察到显著的CNR减少.

结论:

  • 在路线图条件下,大多数LEA和含的对比介质之间存在CNR的显著差异.
  • 在临床实践中,在LEA注射之前,必须考虑这些可见性差异.
  • 这些发现强调了选择具有足够辐射透明度的LEA的重要性,以获得最佳的程序指导.